Osteogenic Sarcoma is a malignant tumor arising from the undifferentiated fibrous tissue of bone, and one of the most common primary malignant tumors of bone. Clinical observation was carried out on 48 cases of oeteogenic sarcoma which were experienced at the Department of Orthopedic Surgery, College of Medicine, Seoul National University from Nov. 1958 till Jun. 1973.
The results were sumarired as follows;
1. Osteogenic sarcoma was the most frequently encoutered malignant bone tumor, consisting of 59.3% of the cases of primary malignant tumor of bone.
2. The peak incidence was in the age group from 11 to 20 years in 25 cases (52.1 % ).
3. The sex distribution was 29 in males and 19 in females.
4. The most commonly affected site was distal femur (33.3%), and 28 cases(58.3%) were around the knee.
5. Increment of serum alkaline phophatase was observed in 22 cases (45.8%), and the average value of serum alkaline phophatase in these cases was I2.2 13odanskq, units.
6. The histopathological study revealed osteoblastic type in 23 cases (52.3%), fibroblastic in 10 cases (22.7%), and chondroblastic in 9 cases (20.5%).
7. Among 48 cases of osteogenic sarcoma, amputation was done in ZI (43.8%), and irradiation in 2 cases. Chemotherapy was done in a case. 21 cases refused amputation and discharged.
8. Follow-up study for 18 months was done in 22 cases; 15 cases died within a year after discharge by pulmonary metastasis, 7 cases survived. A patient who had hindquarter amputation survived more than 10 years.
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